Lifetime history of suicide attempt, or suicidal ideation in past 6 months? History of partial onset seizures or EEG findings indicating partial onset seizures? Clinical trials The European Union Clinical Trials Register allows you to search for protocol and results information on: To demonstrate the efficacy of oral lacosamide LCM vs placebo as adjunctive therapy for uncontrolled primary generalized tonic-clonic PGTC seizures in subjects with idiopathic generalized epilepsy IGE currently taking 1 to 3 concomitant anti-epileptic drugs AEDs independent of the number of prior failed AEDs. Women of child bearing potential must practice contraception according to protocol requirements?
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This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. Little is known about the epidemiology of TLE, because it requires advanced neuroimaging, positive EEG, and appropriate clinical semiology to confirm the diagnosis.
Moreover, recently recognized incidentally detected mesial temporal sclerosis in otherwise healthy individuals and benign temporal epilepsy indicate that the true epidemiology of TLE is underestimated. This article reviews the following aspects of the epidemiology of TLE: definitions, studies describing epidemiological rates, methodological observations, the interpretation of available studies, and recommendations for future studies.
Introduction Epidemiology is the study of disease frequency, its determinants, natural history, and burden of illness in populations [ 1 ]. There are many shortcomings in the understanding of the epidemiology of epilepsy mainly related to methodological problems. Some of them are diagnostic accuracy, case ascertainment, and selection bias [ 2 ]. Information regarding the epidemiology of temporal lobe epilepsy TLE is scanty with few studies and review articles in this subject [ 3 ].
This article reviews some of the published evidence in the area and analyzes the methodological obstacles to perform epidemiological studies in this type of epilepsy. This article explores the following aspects; a review of the available definitions for TLE, measures in epidemiology, and a brief review of the well-knwon epidemiological rates in epilepsy.
The article finishes with the description and analysis of the available epidemiological studies in TLE. Definition of Temporal Lobe Epilepsy Standardized definitions are crucial for epidemiological research. This definition has been used in several epidemiological studies with great success and has helped to understand the burden of epilepsy in different countries [ 6 — 8 ]. A modification in the definition was suggested by Fisher et al.
The new definition requires the occurrence of at least one seizure plus a clear predisposing factor [ 9 ]. This modification could have practical consequences because the prevalence of epilepsy can be overestimated. TLE was included in the classification of the ILAE in under the group of localization-related symptomatic epilepsies.
The definition offers a tentative description based on suggestive clinical features dividing seizures in simple and complex partial seizures plus ictal and interictal electroencephalogram EEG findings [ 10 ]. The definition suggests the use of some findings in additional tests to help in the diagnosis, such as the presence of hypometabolism in proton-emission tomography scan [ 10 ].
The classification of the ILAE also identifies seizures coming from the amygdalo-hippocampal area mesiobasal limbic or rhinencephalic and seizures coming from the lateral temporal area [ 10 ]. The classification released by the ILAE in recognizes some diagnostically meaningful forms of epilepsy such as mesial temporal lobe epilepsy mTLE with hippocampal sclerosis HS that was not included in the previous classifications [ 11 ]. Finally, as Wiebe [ 3 ] pointed out, the previous and current classifications of the ILAE do not rate the diagnosis of TLE and the other types of seizures or syndromes according to the diagnostic certainty, for example, definite, probable, and possible.
Also, there is no weight for diagnostic features specifying major or minor criteria. In general, the positive points of the previous and current classifications are as follows: the diagnosis is based on typical clinical description, there is recognition of anatomical areas, the addition of mTLE with HS which is a common type of syndrome, and the inclusion of some specific features such as genetic, structural, and unknown that may help to classify some etiologies in patients with TLE.
The negative aspects of the available classifications are the exclusion of MRI criteria and video-EEG findings to diagnose and classify patients, especially for patients with no findings in the routine EEG despite a potential clinical description of TLE. The current classifications also do not include diagnostic categories such as definite, probable, and possible.
The latter aspect is a significant disadvantage for the development of large epidemiological studies in TLE. It is age- and gender-adjusted to a standard population and is the most widely used measure of mortality. Epidemiology of Epilepsy 4. Prevalence The prevalence of epilepsy in the developed countries ranges from 4 to 10 cases per 1, [ 1 ].
Studies in the developing and tropical countries have reported a higher prevalence rates of epilepsy, ranging from 14 to 57 cases per 1, persons [ 12 , 13 ]. Higher prevalence rates of epilepsy in the developing countries is probably related to the methodological aspects of those studies, although in some regions in the world, specific infectious diseases are frequent causes of epilepsy such as neurocysticercosis [ 13 ].
Incidence The median incidence rate of epilepsy in the developed countries ranges from 25—50 per , person years while in the developing countries it ranges from approximately 30— per , person years [ 14 ]. In the developed countries, the incidence of epilepsy tends to exhibit a U-shaped curve with highest rates in the children and the elderly. This same pattern has not been found in the developing countries, where the incidence of epilepsy appears to peak in early adulthood.
Mortality SMR in epilepsy ranges from 1. Overall, the information that proves that mortality is increased in patients with epilepsy versus different type of controls is very solid and comes from well-designed controlled studies [ 15 — 17 ].
The majority of the studies have been generated in referral centers providing biased estimates. The best available epidemiological data was provided by the Hauser and Kurland [ 18 ]. This initial epidemiological study explored different epidemiological markers of epilepsy in the community of Rochester Minnesota from to All the cases were assessed by experts in the Mayo Clinic which was the sole provider of neurology service including EEG to that community.
The incidence rate of TLE was In the same periods of time, corresponding incidence rates of epilepsy in the whole population were In the same study, the calculated prevalence of TLE in was 1. In further studies published by Hauser et al. Other estimates regarding the prevalence of epilepsy have been obtained from tertiary referral centers.
Semah et al. In this study, patients The rest of the patients had either generalized epilepsy The study also compares rates of intractability between partial and generalized epilepsy being the first one more intractable.
A study of Manford et al. In this study, general practitioners identified all patients older than one month in whom a new diagnosis of definite or possible epileptic seizures was made during 3 years of recruitment.
The practices of those family physicians were located around the country in urban and rural areas to avoid demographic sources of bias. Patients were followed at six months, and then every year with followup between 4 and 7 years.
Details of hospital and specialist assessments and results of investigations were obtained. The authors had significant problems to identify the localization of the epileptogenic area as many patients did not have video-EEG telemetry. Finally, studies from surgical centers describe the frequency of TLE and report different rates compared with other sources.
For example, Wass et al. Guldvog et al. Keene et al. Rougier et al. All the studies in surgical centers provide similar rates which are significantly higher than other sources. Regarding mortality which is a very relevant outcome in epilepsy, we do not have any reported estimates in patients with TLE.
There are reports from surgical centers with controversial information regarding the improvement of mortality rates in TLE after surgery. Some studies have demonstrated an improvement of mortality rates after epilepsy surgery if patients render seizure-free [ 28 , 29 ], but these observations are not consistent in all studies [ 9 , 30 ]. Patients with TLE from epilepsy centers represent very selected populations and they do not accurately reflect mortality in epilepsy in TLE.
Interpretation of the Published Epidemiological Studies The available studies describing the epidemiology of TLE provide interesting and varied information. The studies by Manford et al. In this study, the patients did not belong to surgical centers or epilepsy centers and were mainly recruited by general practitioners.
This study clearly indicates that TLE is not the most frequent type of epilepsy if we take into account cases with epilepsy from the community. On the other hand, there is no doubt that TLE is the most frequent type of epilepsy that is referred to the surgical centers. The high prevalence of patients with TLE in surgical centers is probably related to the better surgical outcome of TLE compared to extratemporal epilepsy and the higher risk of neurological deficits related to excision of functional cortex in extratemporal cases.
Because of this reason, more neurologists and more family practitioners possibly refer patients with TLE more frequently for surgical assessment. In addition, some studies have demonstrated that TLE has high rates of intractability and it could be another reason why patients are more referred to epilepsy centers. The intermediate rates of TLE reported in tertiary referral centers help us to understand the epidemiology of this entity.
In contrast to the studies from epilepsy surgical centers where a great majority of cases have TLE and from studies based on community referrals where the rate is low, studies from tertiary centers show an intermediate prevalence of TLE. The study of Hauser and Kurland [ 18 ] is unique in many aspects and the methodology that was used in this study is probably the recommended for a large-scale epidemiological study in TLE.
In the study of Hauser and Kurland [ 18 ], all the patients were evaluated in the Mayo Clinic, allowing the possibility to have the assessment from the specialist and the use of other tests to classify the patients with the different types of epilepsy.
In contrast to many epidemiological studies that asses the overall prevalence of epilepsy and where simple methods can be used such as a questionnaire or simple questions to ascertain the diagnosis of epilepsy to obtain accurate estimates, in the specific case of TLE and other partial epilepsies, it would be necessary to have a clinical assessment by specialists and the use of other tests such as EEG, MRI, and in some cases video-EEG telemetry.
Future Research The lack of large-scale epidemiological studies in TLE could be related to real methodological obstacles. Probably the main obstacle is the lack of a clear definition. As was reviewed in this article, the current definition by the ILAE is not easy to apply in large epidemiological studies. Examples of this situation are the studies of Manford et al. Moreover, the definition has to be easy to apply in large populations such as the ILAE definition of epilepsy.
In the earlier epidemiological studies, very little if any neuroimaging was done; it was not yet available. With the expanded use of neuroimaging in the diagnostic evaluation of most patients with seizures and the improvement in imaging technology, we are getting a better understanding of the role of structural lesions in patients with TLE.
Few studies have explored the presence of specific imaging findings related with TLE, such as MTS in normal population or in patients with benign forms of TLE [ 32 , 33 ].
In the future, epidemiological studies using MRI are going to be critical in order to understand better the epidemiology of TLE. Another challenge for future epidemiological studies in TLE is the selection of the population. As we reviewed in this article, a cohort for epidemiological studies on TLE should be based on a community where a hospital with major resources to investigate patients is available. This is necessary considering that many cases cannot be diagnosed only with the clinical history and they will require other specialized tests.
Finally, a significant problem to develop a large epidemiological study is the low incidence and prevalence of TLE. The study of Hauser and Kurland [ 18 ] shows that the rates are low and the necessity of a large sample size for epidemiological studies could be not feasible in many settings.
Acknowledgment J. References 1. CPD—Education and self-assessment. The epidemiology of epilepsy: the size of the problem. The epidemiology of epilepsy: past, present, and future.
CLASIFICACION EPILEPSIA ILAE 2010 PDF
Tygogrel High-gamma HG; Hz activity in macroscopic clinical records is considered a marker for critical brain regions involved in seizure initiation; it is correlated with pathological multiunit firing during neocortical seizures in the seizure core, an area identified by correlated multiunit…. The attempts to replace the ILAE classification of epilepsies have been far from successful. Please send me information about ILAE activities and other information of interest to the epilepsy community. The results tripled the number of known genetic associations for epilepsy and importantly implicated 11 new genes. A putative basis for the partial responsiveness to vigabatrin analogs? We also analyzed the new version according to the principles of a good classification.
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Results indicate that our automated algorithm is an effective method for concept recommendation. Objective To perform a systematic review of compliance with standardized terminology and reporting criteria for radiofrequency RF tumor ablation, proposed by the International Working Group on Image-Guided Tumor Ablation inin the published reports. She is a trustee of The Pituitary Foundation. This information is summarized in Table I. Over the past several years, there has been substantial progress made in the domain coverage and standardization of medical terminology. Hence, further use of the Nomina should be encouraged. Image-guided tumor ablation has become a well-established hallmark of local cancer therapy.
A Review of the Epidemiology of Temporal Lobe Epilepsy
ILAE CLASSIFICATION OF EPILEPSY 1989 FILETYPE PDF