The Erratum to this article has been published in BMC Complementary and Alternative Medicine Abstract Background Arum palaestinum is a plant commonly found in the Middle East that is ingested as an herbal remedy to fight cancer. Methods Verified prostate cancer cells were plated as 3D spheroids to determine the effect of extract from boiled Arum Palaestinum Boiss roots. Control mice 10 mice in each group received vehicle in the same manner and volume. When GZ17 was applied to non-cancer tissue, in this case, human islets, there was no cell death at doses that were toxic to treated cancer cells. Preliminary toxicity studies were conducted on rats using an up-down design, with no signs of toxic effect at the highest dose.

Author:Faejas JoJozil
Country:Cayman Islands
Language:English (Spanish)
Published (Last):6 January 2014
PDF File Size:18.84 Mb
ePub File Size:3.4 Mb
Price:Free* [*Free Regsitration Required]

Table reproduced with permission from Genzada Pharmaceuticals. Changes in body weight in mice treated with GZ17 vs vehicle. Figure reproduced with permission from Genzada Pharmaceuticals. When individual chemical constituents from the major chemical categories of Arum palaestinum are surveyed and connected to published literature, it is seen that a substantial number of the phytochemicals in Arum palaestinum show anticarcinogenic activity in their own right.

The anticancer potential of Arum palaestinum, combined with other emerging areas of therapeutic interest, such as preliminary evidence suggesting potential antinociceptive properties,47 portends an exciting future in the research of this botanical with an already rich ethnobotanical past. Conclusions Arum palaestinum is a botanical with extensive use within Traditional Arabic Palestinian herbal medicine, as well as in other regions of the Mediterranean.

Future human clinical trials are warranted and needed to establish best parameters of use and to understand if extracts of Arum palaestinum may prove useful in the treatment of human carcinomas. Disclosure Statement The author is an independent contractor who was compensated by Genzada Pharmaceuticals for the completion of the review and preparation of the manuscript.

References Arum palaestinum TSN Accessed August 14, A new pyrrole alkaloid isolated from Arum palaestinum Boiss. Arch Pharm Res. Aroids are important medicinal plants. Acta Hortic. Arum TSN Yaniv Z, Dudai N, eds. Medicinal and Aromatic Plants of the Middle-East. Bashar S, Omar S. In vitro antioxidant and antitumor activities of six selected plants used in the Traditional Arabic Palestinian herbal medicine.

Pharm Biol. Traditional knowledge of wild edible plants used in Palestine Northern West Bank : a comparative study. J Ethnobiol Ethnomed. Complementary and alternative medicine use among cancer patients in Palestine with special reference to safety-related concerns. J Ethnopharmacol. Comprehensive metabolite profiling of Arum palaestinum Araceae leaves by using liquid chromatography—tandem mass spectrometry. Food Res Int. Jaradat N, Abualhasan M.

Comparison of phytoconstituents, total phenol contents and free radical scavenging capacities between four Arum species from Jerusalem and Bethlehem.

Pharmacol Sci. Effect of isoorientin isolated from Arum palaestinum on uterine smooth muscle of rats and guinea pigs. Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer. Biochem Pharmacol. Suppression of pro-inflammatory and pro-survival biomarkers in oral cancer patients consuming a black raspberry phytochemical-rich troche. Cancer Prev Res. Oxid Med Cell Longev. OncoTargets Ther. Effects of orientin and vitexin from Trollius chinensis on the growth and apoptosis of esophageal cancer EC cells.

Oncol Lett. Flavonoid C-glucosides derived from flax straw extracts reduce human breast cancer cell growth in vitro and induce apoptosis. Front Pharmacol. J Biol Chem. Luteolin exerts an anticancer effect on NCI-H human non-small cell lung cancer cells through the induction of Sirt1-mediated apoptosis.

Mol Med Rep. Zhong nan da xue xue bao Yi xue ban. Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells.

Cell Biochem Funct. Cytotoxic and anti-metastatic activities of phenolic compounds from Dendrobium ellipsophyllum. Anticancer Res. Anticancer effects of rosemary Rosmarinus officinalis L. Colon adenocarcinoma multidrug resistance reverted by Euphorbia diterpenes: structure-activity relationships and pharmacophore modeling. Anticancer Agents Med Chem. Maslinic acid, a natural triterpene, induces a death receptor-mediated apoptotic mechanism in caco-2 pdeficient colon adenocarcinoma cells.

A review of coumarin derivatives in pharmacotherapy of breast cancer. Curr Med Chem. Glutamic acid and its derivatives: candidates for rational design of anticancer drugs. Future Med Chem. Rosenfeld CS. Antileukemic activity of phenylalanine methyl ester PME : a lysosomotropic peptide methyl ester.

Stem Cells. Wattenberg LW. Inhibition of neoplasia by minor dietary constituents. Cancer Res. Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity. Caffeine and caffeic acid inhibit growth and modify estrogen receptor and insulin-like growth factor I receptor levels in human breast cancer.

Clin Cancer Res. J Agric Food Chem. MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells.

Food Chem Toxicol. Vitexin induces apoptosis by suppressing autophagy in multi-drug resistant colorectal cancer cells. A new human prostate carcinoma cell line, 22Rv1. Expression analysis of caspase-6, caspase-9 and BNIP3 in prostate cancer. Mitochondrial and caspase pathways are involved in the induction of apoptosis by nardosinen in MCF-7 breast cancer cell line. Res Pharm Sci. Wu XX, Kakehi Y. Enhancement of lexatumumab-induced apoptosis in human solid cancer cells by cisplatin in caspase-dependent manner.

Potential risks associated with traditional herbal medicine use in cancer care: a study of Middle Eastern oncology health care professionals. Evaluation of analgesic activity of the methanol extract from the leaves of Arum palaestinum in mice and rats.

Biomed Pharmacol J.


Arum palaestinum (Black Calla Lily)

Received Dec 27; Accepted Jul This article has been cited by other articles in PMC. Abstract Background Arum palaestinum is a plant commonly found in the Middle East that is ingested as an herbal remedy to fight cancer. Methods Verified prostate cancer cells were plated as 3D spheroids to determine the effect of extract from boiled Arum Palaestinum Boiss roots. Control mice 10 mice in each group received vehicle in the same manner and volume.


Arum palaestinum as a Food-Medicine

Gymnomesium Schott Arum is a genus of flowering plants in the family Araceae , native to Europe, northern Africa, and western and central Asia, with the highest species diversity in the Mediterranean region. Plants in closely related Zantedeschia are also called "arum lilies". The flowers are produced in a spadix , surrounded by a 10—cm-long, coloured spathe , which may be white, yellow, brown, or purple; some species are scented, others not. The fruit is a cluster of bright orange or red berries.

Related Articles