The Erratum to this article has been published in BMC Complementary and Alternative Medicine Abstract Background Arum palaestinum is a plant commonly found in the Middle East that is ingested as an herbal remedy to fight cancer. Methods Verified prostate cancer cells were plated as 3D spheroids to determine the effect of extract from boiled Arum Palaestinum Boiss roots. Control mice 10 mice in each group received vehicle in the same manner and volume. When GZ17 was applied to non-cancer tissue, in this case, human islets, there was no cell death at doses that were toxic to treated cancer cells. Preliminary toxicity studies were conducted on rats using an up-down design, with no signs of toxic effect at the highest dose.
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Table reproduced with permission from Genzada Pharmaceuticals. Changes in body weight in mice treated with GZ17 vs vehicle. Figure reproduced with permission from Genzada Pharmaceuticals. When individual chemical constituents from the major chemical categories of Arum palaestinum are surveyed and connected to published literature, it is seen that a substantial number of the phytochemicals in Arum palaestinum show anticarcinogenic activity in their own right.
The anticancer potential of Arum palaestinum, combined with other emerging areas of therapeutic interest, such as preliminary evidence suggesting potential antinociceptive properties,47 portends an exciting future in the research of this botanical with an already rich ethnobotanical past. Conclusions Arum palaestinum is a botanical with extensive use within Traditional Arabic Palestinian herbal medicine, as well as in other regions of the Mediterranean.
Future human clinical trials are warranted and needed to establish best parameters of use and to understand if extracts of Arum palaestinum may prove useful in the treatment of human carcinomas. Disclosure Statement The author is an independent contractor who was compensated by Genzada Pharmaceuticals for the completion of the review and preparation of the manuscript.
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Biomed Pharmacol J.
Arum palaestinum (Black Calla Lily)
Received Dec 27; Accepted Jul This article has been cited by other articles in PMC. Abstract Background Arum palaestinum is a plant commonly found in the Middle East that is ingested as an herbal remedy to fight cancer. Methods Verified prostate cancer cells were plated as 3D spheroids to determine the effect of extract from boiled Arum Palaestinum Boiss roots. Control mice 10 mice in each group received vehicle in the same manner and volume.
Arum palaestinum as a Food-Medicine
Gymnomesium Schott Arum is a genus of flowering plants in the family Araceae , native to Europe, northern Africa, and western and central Asia, with the highest species diversity in the Mediterranean region. Plants in closely related Zantedeschia are also called "arum lilies". The flowers are produced in a spadix , surrounded by a 10—cm-long, coloured spathe , which may be white, yellow, brown, or purple; some species are scented, others not. The fruit is a cluster of bright orange or red berries.