ISOSTERISM AND BIOISOSTERISM IN DRUG DESIGN PDF

Posted on March 21, by mcb An excellent J. The author gives a brief introduction to the concept of biosisosterism classical and non-classical but concentrates on pulling together numerous recent examples which together illustrate the use of bioisosteres to address a diverse range of issues that are commonly encountered in the process of drug discovery. A really nice paper and highly recommended reading material. Isosteres of Hydrogen: Deuterium as an isostere of hydrogen. Deuterium substitution to modulate metabolism.

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This will encourage research and help in the pursuit of a worth-while objective, be it the enrichment of knowledge or the elaboration of a practical purpose. A medicinal scientist who hopes to find a new biologically active drug will have to be guided by such considerations. This process is experimental and the keywords may be updated as the learning algorithm improves. This is a preview of subscription content, log in to check access.

Preview Unable to display preview. Download preview PDF. References M. Hollenberg, J. Google Scholar 2. Moir, J. Google Scholar 3. Moir, Chem. News, ,, , , Google Scholar 4. Hinsberg, J. Google Scholar 5.

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Fujita, J. Isawa, and C. Hansch, J. Hansch, in: Drug Design. Ariens, Ed. Academic Press, New York I, Chap.

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Isosterism and bioisosterism in drug design.

Dut All lily of the valley flower Bioisostere increase target interaction and selectivity: Drug Discovery, Design and Development: Bioisosterism is used to reduce toxicity, change bioavailabilityor modify the activity of the lead compound, and may alter the metabolism of the lead. The main use of this term and its techniques are related to pharmaceutical sciences. Because the fluorine atom is similar in size to the hydrogen atom the overall topology of the molecule is not significantly affected, leaving the desired biological activity unaffected. Bivalent atom or groups.

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Isosterism and bioisosterism in drug design

This will encourage research and help in the pursuit of a worth-while objective, be it the enrichment of knowledge or the elaboration of a practical purpose. A medicinal scientist who hopes to find a new biologically active drug will have to be guided by such considerations. This process is experimental and the keywords may be updated as the learning algorithm improves. This is a preview of subscription content, log in to check access. Preview Unable to display preview.

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ISOSTERISM AND BIOISOSTERISM IN DRUG DESIGN PDF

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